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KMID : 0895420130230020108
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Journal of Korean Society of Occupational and Enviromental Hygiene
2013 Volume.23 No. 2 p.108 ~ p.113
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Applicability of Serum Krebs von den lungen-6 as a Biological Exposure Index for Workers Exposed to Indium
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Won Yong-Lim
Yi Gwang-Yong
Lee Mi-Young
Kim Eun-A
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Abstract
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Objectives: Although several cases of lung diseases caused by indium have been reported in Japan, the United States and China, South Korea, which is estimated to have been the world’ largest consumer of indium, has not yet established a criteria for the diagnosis of lung diseases caused by indium exposure. In this study, we tried to determine the applicability of the Krebs von den lungen-6, which has been widely recognized for its use with interstitial lung disease in Japan, as a biological exposure index for indium.
Methods: Methods: The analysis of indium in serum was conducted by inductively coupled plasma mass spectrometry and the analysis of KL-6 in serum was carried out using enzyme-linked immunosorbent assay kit.
Results: The indium levels in serum were distributed from below the detection limit to a peak of 125.78 μg/L, and the values of the KL-6 were distributed from 104.5 U/mL to 2162.2 U/mL. The serum indium and KL-6 showed good correlation (R2=0.389,pfortrend=0.000) and smoking did not affect the KL-6.
Conclusions: The usefulness of KL-6 as a specific biomarker for interstitial lung disease has been recognized. In addition, it is expected that effective prevention of health problems can be achieved by determining the lung-damage progress at an early stage according to individual susceptibility.
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KEYWORD
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indium, indium-tin oxide, KL-6
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